Craig Venter and the Genome Revolution
I see this morning that Craig Venter passed away yesterday. See the press release from JCVI for more. I never met Venter, but he had a massive influence on my career (believe it or not). As I recall the story, Venter basically sparked the genome revolution with his idea for a "shotgun" approach to genome sequencing. The E.coli genome project at the time was doing a map and sequence technique, where they basically stepped along the genome and sequenced one part at a time. Venter saw this as a huge inefficiency and said that we ought to just break a bacterial genome into lots of pieces, sequence a bunch of them, then let a computer reconstruct the complete chromosome from the sequenced fragments. Venter's plan required eight times as much sequencing as the E.coli project, but Venter expected that the cost of sequencing would come down (which it did) and the speed improvement would be HUGE (which it was). NSF reviewers were skeptical of the plan, but he did some proof-of-...