Denisova again
Remember that Denisova mtDNA sequence from Siberia? The one published earlier this year that was more different from modern humans than Neandertals? In this week's Nature , the same research team has published the full nuclear genome of Denisova . It answers some of my questions and raises new ones. Some thoughts: 1. The genome is more similar to the Neandertals than to modern humans, which is different from the mitochondrial genome analysis , which placed Neandertals and humans together as sisters, with Denisova as the outgroup. The authors (Reich et al.) hypothesize that this represents incomplete lineage sorting, which is a phenomenon that occurs in the early stages of speciation when different genes have different phylogenetic histories. 2. They sequenced a second Denisovan mtDNA genome from a tooth found at the same site. This mtDNA genome differed from the first Denisovan mtDNA genome by only two nucleotide positions. This second mtDNA genome gives independent confirmati...